3138 The Efficiency of Immunotherapy to the Subjects with Allergy to Bee Venom and Its Influence in Pollen Allergy

Friday, 16 October 2015
Hall D1 Foyer (Floor 3) (Coex Convention Center)

Leonora Hana-Lleshi, Specialist, MD , Allergology&immunology, Regional Hospital, Gjakova, Kosovo

Luljeta Ahmetaj, PhD candidate , Department of Physiology and Immunology, Medical Faculty, University of Prishtina, Prishtina, Kosovo

Anila Toka Shkurti , Chief of the Ambulatory Service, National Trauma Universitary Hospital of Albania, Tirana, Albania

Etleva Qirko Loloci , University Hospital Center, Tirana, Albania

INTRODUCTION: Hymenoptera venom allergy is an immunoglobulin E (IgE)- mediated hypersensitivity to the venom of the insect order Hymenoptera.

This allergic reaction may be caused by stings from a number of species in this insect order, occurring only in persons who have previously been sensitized to Hymenoptera venom.


-SIGNS AND SYMPTOMS:Most Hymenoptera stings cause small local reactions of no significant medical consequence,these usually peak in intensity at 48 to 72 hours.

 Large local sting reactions typically resolve gradually over 5 to 10 days

Systemic reactions cause signs and symptoms in one or more organ systems and are almost always IgE-mediated.

Systemic reactions usually cause signs and symptoms starting with in minutes following a sting. In general, the sooner the symptoms occur, the more severe the reaction is.

-PATHOPHYSIOLOGY:Both systemic and large local reactions to stinging insects are usually caused by IgE-mediated reactions to Hymenoptera venom.  At least one prior sting is required to sensitize a person to venom, and sensitization is more likely to occur following multiple simultaneous stings or subsequent stings occurring over a relatively short period of time.  Once sensitization has occurred, a sting can cause mast cell and basophil degranulation, resulting in release of the histamine and other inflammatory mediators responsible for the signs and symptoms of anaphylactic and some large local reactions.

  Allergic reactions to bee venom can be severe enough to cause anaphylactic shock, which can be fatal.

-ALLERGY EFFICACY OF VIT(Venom immunotherapy):VIT is extremely efficacious in preventing subsequent systemic reactions in patients with stinging insect allergy. Efficacy is highest with mixed vespid venom; it is 98% effective in preventing subsequent systemic reactions with a maintenance dose of 300 μg (100 μg per venom )

During the period of two years of VIT in one case, of my observed patient, I verified that the subject 12 years old; gender: female was allergic in: pollens and bee venom with anaphylactic allergic reaction.  Specific Ig- E was  detected with POLYCHECK (Bio-Check). Until now I’m performing by schematic regimen SCIT in the upper external side of arm and every time the patient is under my observation for 30 minutes After one year of VIT with Anallergo vaccine, the patient has repeated Specific Ig-E on pollens and hymenoptera venoms, with the parameters of: Bee venom has fallen  from 5-4;Alder pollen: 1-0;Birch pollen : 2-0; Hazelnut pollen: 2-1;Beech pollen: 2-0;Oak pollen: 2-1;Pine: 2-0;Rhizopus nigrans:2-0;Grass mix:

 3-1 and house dust from 2-0.



-MATHERIAL AND METHODS:    L-Tyrosine-adsorbed subcutaneous immunotherapy (SCIT) for hymenoptera venom ANALLERGO (Apis mellifera)

CONCLUSION:So I need to follow 1-3 years the patients analysis for definitive conclusion about the efficiency of VIT and its correlation of positive influence to pollen  allergy?