Wednesday, 14 October 2015
Hall D1 Foyer (Floor 3) (Coex Convention Center)
Min-Hye Kim, MD
,
Internal Medicine, Ewha Womans University, School of Medicine, Seoul, South Korea
Da-Jeong Bae
,
Division of Allergy and Respiratory Medicine, Soonchunhyang University Bucheon Hospital, Bucheon, South Korea
Hyun Ji Song
,
Division of Allergy and Respiratory Medicine, Soonchunhyang University Bucheon Hospital, Bucheon, South Korea
Taehyeong Lee
,
Division of Allergy and Respiratory Medicine, Soonchunhyang University Bucheon Hospital, Bucheon, South Korea
Ji Ah Jun
,
Division of Allergy and Respiratory Medicine, Soonchunhyang University Bucheon Hospital, Bucheon, South Korea
Jong-Sook Park, MD
,
Division of Allergy and Respiratory Medicine, Soonchunhyang University Bucheon Hospital, Bucheon, South Korea
An-Soo Jang
,
Division of Allergy and Respiratory Medicine, Soonchunhyang University Bucheon Hospital, Bucheon, South Korea
Hun Soo Chang, PhD
,
Division of Allergy and Respiratory Medicine, Soonchunhyang University Bucheon Hospital, Bucheon, South Korea
Young Joo Cho, MD, PhD
,
Internal Medicine, Ewha Womans University, School of Medicine, Seoul, South Korea
Choon-Sik Park, MD., PhD.
,
Division of Allergy and Respiratory Medicine, Soonchunhyang University Bucheon Hospital, Bucheon, South Korea
Background: Neutrophilic airway inflammation is often observed in non-atopic adult asthma. Interleukin 8 (IL8) is a potent pro-inflammatory cytokine recruiting and activating neutrophils. The relation of IL8 has been revealed with exacerbation of asthma, however its role has not been revealed in terms of prognosis in asthma. The aim of the study was to investigate the relation of sputum IL-8with inflammatory phenotypes, severity and long - term prognosis of asthma.
Materials and Methods:Hypertonic saline induced sputum was obtained from asthma in stable state (n=88) and in exacerbation (n=55). Differential cell count was done. IL-8 was measured using sandwich ELISA. The levels were analyzed in terms of airway obstruction (FEV1) and inflammation (neutrophil and eosinophil % of the airway) and exacerbation frequency and lung functions over 1 year or longer follow up.
Results: IL-8 levels were significantly correlated with the percentages of neutrophils (r=207, p=0.012) and neutrophils count (r=0.277, p=0.001) in sputum, and inversely with the levels of FEV1% (r=-0.277, p=0.028) in total asthmatics. The correlations of IL-8 levels with percentages of neutrophils (r=0.312, p=0.003) and FEV1% (r=-0.252, p=0.018) were also observed in stable asthmatics. In the exacerbation group, IL-8 levels were inversely correlated with FEV1% predicted values (r=-0.272, p=0.045). In long term follow up over more than 1 year, IL-8levels were positively correlated with annual number of exacerbation (n=109, r=0.227, p=0.017).
Conclusion: sputum IL-8 is related with neutrophilc inflammation rather than eosinophilc inflammation of asthma. In long - term follow up of asthma, increase of sputum IL-8 may be one of susceptible factors for frequenct exacerbation.
