Presentation: Perinatal Maternal Distress Is Associated with Development of Offspring's Atopic Dermatitis ( World Allergy Congress)

Friday, 16 October 2015: 16:15 - 16:30

Room R2 ABC (Floor 3) (Coex Convention Center)

Ji-Won Kwon, MD , Seoul National University Bundang Hospital, Seongnam, South Korea

Young-Ho Kim, MD , Department of Pediatrics, Childhood Asthma Atopy Center, Enviromental Health Center, University of Ulsan College of Medicine,, Asan Medical Center, Seoul, South Korea

Song-I Yang, MD , Asan Medical Center, seoul, South Korea

Eun Lee, MD , Department of Pediatrics, Childhood Asthma Atopy Center, Enviromental Health Center, University of Ulsan College of Medicine,, Asan Medical Center, Seoul, South Korea

Hyung Young Kim, MD , Department of Pediatrics, Pusan National University Yangsan Hospital, Yangsan, South Korea

Young-Ho Jung, MD , Department of Pediatrics, Bundang CHA Medical Center, CHA University School of Medicine, Seongnam, South Korea

Ju-Hee Seo, MD , Department of Pediatrics, Korea Cancer Center Hospital, Seoul, South Korea

Hyo-Bin Kim, MD , Department of Pediatrics, Inje University Sanggye Paik Hospital, Seoul, South Korea

So-Yeon Lee, MD , Department of Pediatrics, Hallym University Sacred Heart Hospital, Anyang, South Korea

Soo-Jong Hong, MD, PhD , Department of Pediatrics, Childhood Asthma Atopy Center, Environmental Health Center, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea

Background: The development of allergic disease has been thought to the results of immunologic response to various genetic and environmental factors. Perinatal environments including maternal psychological distress might be related with development of allergic diseases.

Purpose: We evaluated the influences of maternal prenatal depression for the development of offspring’s atopic dermatitis (AD).

Methods: A total of 2,150 pregnant women were enrolled from general population between April 2008 and January 2009. Kessler scores for the probability of mother’s distress were calculated at one month before and six month after delivery. Korean version of ISAAC (International Study of Asthma and Allergies in Childhood) questionnaire was obtained to evaluate the offspring’s prevalence of allergic diseases at the age of 5. Logistic regression analyses were performed to analyze the association between perinatal maternal depression scores and the development of atopic dermatitis.

Results: The prevalence (95% CI) of recent itchy eczema and physician diagnosed AD at 5 years old were 23.1 % (21.0-25.3) and 25.9 % (23.7-28.1). Children with current AD (having both physician diagnosed AD and recent eczema) was 14.1 % (12.4-15.8). Offsprings from the mothers with high Kessler score (≥ 19) in one month before delivery were more likely to have a history of recent AD treatment (aOR 1.93, 95% CI 1.04-3.59) and current AD (aOR 1.72, 95% CI 0.94-3.13) at age 5. Persistent maternal distress (Kessler score ≥ 19 at one month before and 6 months after delivery) was also associated with physician diagnosed AD (aOR 2.61, 95% CI 1.02-6.67).

Conclusion: Prenatal maternal distress might influence the development of offspring’s AD. This finding suggests the possibility of AD prevention according to control of maternal depression in pregnancy.

9-4OAS Perinatal Maternal Distress Is Associated with Development of Offspring's Atopic Dermatitis