Hyun-Ju Cho, MD
,
Department of Pediatrics, Childhood Asthma Atopy Center, Environmental Health Center, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea
Youn Ho Shin, MD
,
CHA Medical Center, Seoul, South Korea
Eun Lee, MD
,
Department of Pediatrics, Childhood Asthma Atopy Center, Enviromental Health Center, University of Ulsan College of Medicine,, Asan Medical Center, Seoul, South Korea
Young-Ho Kim, MD
,
Department of Pediatrics, Childhood Asthma Atopy Center, Enviromental Health Center, University of Ulsan College of Medicine,, Asan Medical Center, Seoul, South Korea
Darae Lee, MD
,
Asan Medical Center, Seoul, South Korea
Mi-Jin Kang, MS
,
Asan Institute for Life Science, Asan Medical Center, Seoul, South Korea
Song-I Yang, MD
,
Department of Pediatrics, Hallym University Sacred Heart Hospital, Anyang, South Korea
Kangmo Ahn, MD, PhD
,
Environmental Health Center for Atopic Diseases, Samsung Medical Center, Seoul, South Korea
Kyung Won Kim, MD, PhD
,
Department of Pediatrics and Institute of Allergy, Yonsei University College of Medicine, Seoul, South Korea
Yoon Hee Kim, MD
,
Department of Pediatrics and Institute of Allergy, Brain Korea 21 PLUS Project for Medical Science, Yonsei University College of Medicine, Seoul, South Korea
Dongin Suh, MD
,
Department of Pediatrics, Seoul National University Hospital, Seoul, South Korea
Hye-Sung Won
,
Asan Medical Center, Seoul, South Korea
Soo Hyun Kim
,
CHA Medical Center, Seoul, South Korea
Suk-Joo Choi
,
Samsung Medical Center, Seoul, South Korea
Young Han Kim
,
Yonsei University College of Medicine, Seoul, South Korea
Jong Kwan Jun
,
Seoul National University College of Medicine, Seoul, South Korea
Eun-Jin Kim
,
Korea National Institute of Health, Osong, South Korea
Jeom Gyu Lee
,
Korea National Institute of Health, Osong, South Korea
So-Yeon Lee, MD
,
Department of Pediatrics, Hallym University Sacred Heart Hospital, Anyang, South Korea
Soo-Jong Hong, MD, PhD
,
Department of Pediatrics, Childhood Asthma Atopy Center, Environmental Health Center, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea
Background: The association between serum vitamin D deficiency at birth and atopic dermatitis (AD) is uncertain. The aim of this study was to investigate the relationship between cord serum 25(OH)D on the development of AD with a prospective birth cohort study.
Methods: Children aged 0 through 3 yr from a birth cohort in the Cohort for Childhood Origin of Asthma and allergic diseases (COCOA) study were enrolled. The cord blood obtained from 655 at birth . The 25(OH)D and DNA from their cord blood are measured and specific IgE antibodies against egg and milk were performed at 1, 3yr of age. Also skin prick test were conducted at 3yr of age.
Results: The median cord serum 25(OH)D was 17.9 ng/ml. Low cord serum 25(OH)D (<20 ng/mL) is associated with milk sensitization at 1yr of age. Severe cord serum 25(OH)D deficiency (<10 ng/mL) increased the risk of AD at age 2 (aOR, 3.287; 95% CI, 1.587-6.808; p-value, 0.001) and age 3 (aOR, 2.686; 95% CI, 1.167-6.182; p-value, 0.020). We also found that cord serum 25(OH)D may affect outcome of AD. Low cord serum 25(OH)D reduced the remission of AD (aOR, 0.321; 95% CI, 0.96-1.072; p-value, 0.065) and severe deficiency ((<10 ng/mL) is associated with newly development of AD (aOR, 8.446; 95% CI, 0.905-78.792; p-value, 0.061).
Conclusions: Cord serum 25(OH)D were associated with milk sensitization and AD. And low cord serum 25(OH)D reduce the remission of AD and severe deficiency is associated with newly development of AD. These data suggest that cord serum 25(OH)D affect the development and prognosis of AD.
