Methods: Children aged 0 through 3 yr from a birth cohort in the Cohort for Childhood Origin of Asthma and allergic diseases (COCOA) study were enrolled. The cord blood obtained from 655 at birth . The 25(OH)D and DNA from their cord blood are measured and specific IgE antibodies against egg and milk were performed at 1, 3yr of age. Also skin prick test were conducted at 3yr of age.
Results: The median cord serum 25(OH)D was 17.9 ng/ml. Low cord serum 25(OH)D (<20 ng/mL) is associated with milk sensitization at 1yr of age. Severe cord serum 25(OH)D deficiency (<10 ng/mL) increased the risk of AD at age 2 (aOR, 3.287; 95% CI, 1.587-6.808; p-value, 0.001) and age 3 (aOR, 2.686; 95% CI, 1.167-6.182; p-value, 0.020). We also found that cord serum 25(OH)D may affect outcome of AD. Low cord serum 25(OH)D reduced the remission of AD (aOR, 0.321; 95% CI, 0.96-1.072; p-value, 0.065) and severe deficiency ((<10 ng/mL) is associated with newly development of AD (aOR, 8.446; 95% CI, 0.905-78.792; p-value, 0.061).
Conclusions: Cord serum 25(OH)D were associated with milk sensitization and AD. And low cord serum 25(OH)D reduce the remission of AD and severe deficiency is associated with newly development of AD. These data suggest that cord serum 25(OH)D affect the development and prognosis of AD.