In outpatient clinic, we meet many patients who are suffering from allergic disease. In our department, we usually ask the patient, who is suffering from allergic diseases such as allergic rhinitis, to take blood test after giving informed consent. We calculate the ratio of eosinophils, the level of non-specific and specific IgE, and so on. However, the ratio of eosinophils is fluctuated, and there seems to be no connection between the level of non-specific IgE and the severity of allergic disease. In this study, we retrospectively studied whether the results of blood test are associated with the relevance of allergic disease or not.
We sampled 64 patients (32 men and 32 women) who visited our department and took blood test from January 2014 to December 2014. We measured the ratio of eosinophils, the level of non-specific and specific IgE, and so on. In this study, we divided these patients into 4 groups according to the level of non-specific IgE (less than 100 <Group 1>, 100 or more and less than 500 <Group 2>, 500 or more and less than 1000 <Group 3>, more than 1000 <Group 4>). Then we investigated them from several aspects.
The most common disease in Group 1 is seasonal allergic rhinitis (44.7%), followed by vasomotor rhinitis (28.9%) and perennial allergic rhinitis (21.1%). Group 2 has the same tendency as Group 1 (seasonal allergic rhinitis (47.1%), vasomotor rhinitis (29.4%), perennial allergic rhinitis (23.5%)). Group 3 and Group4 have small number of patients. It is difficult to calculate the percentage of diseases in both groups, but seasonal allergic rhinitis and chronic sinusitis were tending to have high relevance.
Next, we evaluated the relationship between the level of non-specific IgE and the relevance of diseases. In Group 4, the relevance of chronic sinusitis and perennial allergic rhinitis was significantly higher than Group 1. Eosinophilic sinusitis, seasonal allergic rhinitis, and vasomotor rhinitis had no significant differences.
Non-specific IgE level may be related to the severity of chronic sinusitis and perennial allergic rhinitis. Non-specific IgE level may also be useful in order to estimate the future relevance and severity of nasal diseases.