Presentation: Two Cases of Good's Syndrome: A Rare Acquired Immunodeficiency Associated with Thymoma ( World Allergy Congress)

Saturday, 17 October 2015

Hall D1 Foyer (Floor 3) (Coex Convention Center)

Suk Yeon Kim, MD , Department of Internal Medicine, Hallym University Sacred Heart Hospital, Anyang, South Korea

Joo-Hee Kim, MD , Pulmonology and Allergy, Hallym University, College of Medicine, Chuncheon, South Korea

Sunghoon Park, MD, PhD , Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, Hallym University Sacred Heart Hospital, Anyang, South Korea

Young Il Hwang , Hallym University Sacred Heart Hospital, South Korea

Seung Hun Jang, MD, PhD , Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, Hallym University Sacred Heart Hospital, Anyang, South Korea

Ki-Suck Jung , Division of Pulmonary, Allergy and Critical Care Medicine, Hallym University Sacred Heart Hospital, Anyang, South Korea

Ha Won Hwang , Hallym University Sacred Heart Hospital, South Korea

Kwang Youn Kim , Hallym University Sacred Heart Hospital, South Korea

Good’s syndrome is an acquired immunodeficiency state associated with thymoma. It is characterized by recurrent infection, autoimmune disease, and immunologic abnormality. The insufficient immunity can be supported by intravenous immunoglobulin(IVIG) replacement therapy. We describe 2 patients who presented with cough and dyspnea caused by Pneumocystis jiroveci pneumonia and Cytomegalovirus pneumonia respectively after thymectomy for a thymoma. Immunologic study revealed hypogammaglobulinemia with very low B-cell count, consistent with Good’s syndrome. They were successfully treated with trimethoprim/sulfamethoxazole and gancyclovir respectively, and now they are doing well without additional infections, having regular IVIG replacement.

4045 Two Cases of Good's Syndrome: A Rare Acquired Immunodeficiency Associated with Thymoma