Presentation: Relationship Between Lipid Levels and Risks of Allergic and Respiratory Diseases in Early Childhood: The Mothers and Children's Environmental Health Study ( World Allergy Congress)

Friday, 16 October 2015

Hall D1 Foyer (Floor 3) (Coex Convention Center)

Ja Hyeong Kim, MD , 1Department of Pediatrics, Ulsan University Hospital, Ulsan, South Korea

Eun-Hee Ha, MD , Department of Preventive Medicine, Ewha Womans University, Seoul, South Korea

Hyesook Park, MD , Department of Preventive Medicine, Ewha Womans University, Seoul, South Korea

Mina Ha, MD , Department of Preventive Medicine, Dankook University College of Medicine, Cheonan, South Korea

Yun-Chul Hong, MD , Department of Preventive Medicine, Seoul National University College of Medicine, Seoul, South Korea

Yangho Kim, MD , Department of Occupational and Environmental Medicine, Ulsan University Hospital, Ulsan, South Korea

Namsoo Chang, PhD , Department of Nutritional Science and Food Management, Ewha Womans University, Seoul, South Korea

Background: Recent studies suggest that dietary change may influence programming of the immune system in favor of development of allergic disease. However, the results for the effect of fat status on development of allergic or respiratory disease in children are still conflicting.

Methods: A total 426 children were included in this study from a birth cohort in South Korea. Data regarding the children’s allergic and respiratory outcomes were obtained from standardized questionnaires completed by the mothers. Serum total cholesterol, triglyceride (TG) and high-density cholesterol (HDL) levels were measured in children at 24 months of age. Atopic biomarkers including total Ig E, IL-10 and eosinophil counts were also measured at 24 months.

Results: Serum HDL cholesterol levels were inversely associated with the eosinophil counts counts (r = - 0.221, P < 0.001). Total IgE , eosinophil counts, and IL-10 levels increased significantly in the group whose serum HDL cholesterol levels was above the median value (51mg/dL) compared to the other counterpart group (P = 0.014, P = 0.003, P = 0.040 respectively). However, there was no association between lipid levels and risks of respiratory outcomes and AD at 24 months in logistic regression analysis.

Conclusions: We found that the HDL cholesterol levels were associated with lower atopic biomarkers in children at 24 months, but not with risk of allergic or respiratory diseases.

3181 Relationship Between Lipid Levels and Risks of Allergic and Respiratory Diseases in Early Childhood: The Mothers and Children's Environmental Health Study