2071 The Power of Allergen Specific Ig E in the Classification of Rhinitis, Korean National Hanes 2010

Thursday, 15 October 2015
Hall D1 Foyer (Floor 3) (Coex Convention Center)

Seung Kyu Chung, MD , ORL-Hns, Samsung Medical Center, SEOUL, South Korea

Sujin Kim, MD , ORL-Hns, Samsung Medical Center,, Seoul, South Korea

Sang Duk Hong, MD , Otorhinolaryngology, Samsung Medical Center, Seoul, South Korea

Hyo Yeol Kim Hyo Yeol Kim, MD, PhD , Otorhinolaryngology, Samsung Medical Center, Seoul, South Korea

Hun-Jong Dhong, MD, PhD , Dept of Otorhinolaryngology-Head & Neck Surgery, Samsung Seoul Hospital, Seoul, South Korea

Jong in Jeong, MD , ORL-Hns, Samsung Medical Center,, Seoul, South Korea

A)   Background: Usually rhinitis is classified simply allergic and non-allergic rhinitis according to the allergic reaction to airborne allergens. Ig E–mediated inflammation is confirmed with positive skin test or presence of specific IgE and the positive result from the one of the two tests is usually enough for the diagnosis do allergic rhinitis. We are interested in the diagnostic power of the allergen specific Ig E.  Recently, during Korean National Health and Nutrition Examination Survey 2010, presence of rhinitis and the specific Ig E for major airborne allergens were checked in the population.  Purpose of this study is to evaluate the significance of allergen specific Ig E in the diagnosis of allergic rhinitis.

B)   Method: The data were obtained from the 2010 Korean National HANES, which was a cross-sectional survey of non-institutionalized population all around the country.  Presence of rhinitis was defined as “Have you experience the rhinitis symptoms” or “Have you diagnosed as have allergic rhinitis from doctor”.  Serum specific IgE was checked for Dermatophagoides farinae, cockroach and dog.  Data was obtained from 1,922 adult (older than 18).  The positive predictive values (PPV) of allergen specific IgE on the diagnosis of allergic rhinitis were calculated according to the level of the specific Ig E.

C) Results: The specific Ig E higher than 0.34 kU/L(+) was found in 63.6 % in population with rhinitis and 39.7 %in the population without rhinitis.  The PPVs were 61% with level of 0.35 kU/L and 66% with the level of 3.5 kU/L(+++).  The prevalence of the allergic rhinitis increased with the increasing levels of the specific IgE, from 37.3 % to 77.4 % and the PPV also increased. However the positive predictive rate was 72.4 % with the level of 3.5 kU/L and 82.6 % with the level of 17.5 kU/L(++++).

D) Conclusion: Diagnostic power of specific IgE on the classification of rhinitis is not high and the level of specific Ig E higher than 3.50 kU/L may be more clinically significant.