Thursday, 15 October 2015
Hall D1 Foyer (Floor 3) (Coex Convention Center)
Young-Hee Nam, MD
,
Internal Medicine, Dong-a University School of Medicine, Busan, South Korea
Soo Jin Kim, MD
,
Internal Medicine, Dong-a University School of Medicine, Busan, South Korea
Ji Young Juong, MD
,
Internal Medicine, Dong-a University School of Medicine, Busan, South Korea
Eun Young Kim, MD
,
Internal Medicine, Dong-a University School of Medicine, Busan, South Korea
Su Mi Lee, MD
,
Internal Medicine, Dong-a University School of Medicine, Busan, South Korea
Young Ki Son, MD
,
Internal Medicine, Dong-a University School of Medicine, Busan, South Korea
Hee-Joo Nam
,
Dong-a University Hospital Regional Pharmacovigilance Center, Busan, South Korea
KI-HO KIM, MD
,
Dermatology, Dong-a University School of Medicine, Busan, South Korea
Soo-Keol Lee, MD, PhD
,
Internal Medicine, Dong-a University School of Medicine, Busan, South Korea
Drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome is a rare and severe drug-induced hypersensitivity syndrome characterized by hematological abnormalities and multiorgan involvement. Liver involvement is the most common visceral manifestation. However, renal failure has been rarely described. The common culprit drugs are anticonvulsants and allopurinol. We experienced a patient with DRESS syndrome with acute interstitial nephritis caused by concomitant administration of quinolone and non-steroidal anti-inflammatory drugs (NSAIDs).
A 41-year-old man presented with a diffuse erythematous rash and fever which developed after administration of quinolone and NSAIDs for a month due to prostatitis. He was diagnosed with DRESS syndrome. Skin rash, fever, eosinophilia, and elevations of liver enzymes improved with conservative treatment and discontinuation of the causative drugs. However, deterioration of his renal function occurred on day 8 of admission. The levels of blood urea nitrogen and serum creatinine increased and oliguria, proteinuria and urinary eosinophils were observed. Ultrasonography showed diffuse renal enlargement. The clinical features were compatible with acute interstitial nephritis. Despite intravenous rehydration and diuretics, renal function did not improve. After hemodialysis, his renal function recovered completely within 2 weeks without administration of systemic corticosteroid.
Acknowledgement
This research was supported by a grant from Ministry of Food and Drug Safety to operation of the regional pharmacovigilance center in 2015.
