Methods 40 children(4.6±2.6yr) from 209 patients with allergic respiratory diseases（Jun to August） in 2013 and 2014 as the experimental group，detecting 11 kinds of serum specific IgE and total IgE antibody. 40 health children as control group,both using Elecsys to detect the Vit D concentration.
Results The Vit D average concentration of the experimental group is 35.4±9.7ng/ml(Male 35.4 ±10.3ng/ml,Female35.3±9.1 ng/ml),the control group is 33.3±9.8 ng/ml(Male 30.4±8.4 ng/ml,Female36.3±10.4 ng/ml),there were no significant difference between two groups and sex.Age and Vit D concentration were negatively correlated(experimental group:rs=-0.605, p=0.000; control group: rs=-0.328, p=0.039)．In experimental group ,levels of total and Dp specific IgE were negatively correlated with serum concentration of vitamin D (rs=-0.579, p=0.001; rs =-0.334, p=0.035, respectively), level of cow’s milk specific IgE was positively correlated with serum concentration of vitamin D (rs=0.544, p=0.000).Using multivariate linear regression analysis after adjusted with sex and age,there is significant association between the total IgE and serum vitamin D (B -4.386, 95%CI -8.488- -0.285, p=0.037) in 40 children with allergic respiratory diseases,and also significant association between both total and Dp specific IgE and serum vitamin D (B -9.56, 95%CI -15.405- -3.715, p=0.003; B -0.857, 95%CI -1.561- -0.153, p=0.02, respectively) in 21 children with Dp sensitization.
Conclusions Serum Vit D level could be associated with an increased risk of allergic disease development.