Presentation: Different Inflammatory Mechanisms of Human Metapneumovirus and Respiratory Syncytial Virus ( World Allergy Congress)

Wednesday, 14 October 2015

Hall D1 Foyer (Floor 3) (Coex Convention Center)

Jin-Sung Park, MD , Asthma Allergy Center, Sanggye Paik Hospital, Seoul, South Korea

Eunmi Kwon, CRN , Asthma Allergy Center, Sanggye Paik Hospital, Seoul, South Korea

Zac Callaway, PhD , Ulsan University, Ulsan, South Korea

Takao Fujisawa, MD, PhD , Allergy Center, Mie National Hospital, Tsu, Japan

Chang-Keun Kim, MD, PhD , Asthma and Allergy Center, Inje University Sanggye Paik Hospital, Seoul, South Korea

Background: Human metapneumovirus (HMPV) and respiratory syncytial virus (RSV) share some epidemiological and clinical characteristics; however, few studies have examined whether these viruses induce similar cytokine responses. This study compared cytokine profiles in HMPV and RSV patients to investigate their inflammatory pathways.

Methods: 128 nasopharyngeal aspirate specimens were collected from 128 pediatric patients hospitalized with acute respiratory infection including wheezing and tested for 7 common respiratory viruses. They were divided into HMPV (n=27) and RSV groups (n=101). Th1(IFN-γ), Th2(IL-4, IL-13) and Th17(IL-1β) cytokine profiles were analyzed.

Results: IFN-γ levels in the 2 groups were statistically similar (P=0.08). IL-4 levels were significantly higher in the RSV compared to HMPV group (P<0.0001). IL-13 levels in both groups were under detection level. IL-1β levels were significantly higher in the HMPV compared to the RSV group (P<0.0001).

Conclusion: Our results suggest that HMPV and RSV have different inflammatory mechanisms. HMPV induces airway inflammation by the Th17 pathway through release of IL-1β, whereas RSV acts through the Th2 pathway.

1145 Different Inflammatory Mechanisms of Human Metapneumovirus and Respiratory Syncytial Virus