1107 MicroRNA-432 modulates Th1 responses and induced therapeutic effects in atopic like murine model.

Wednesday, 14 October 2015
Hall D1 Foyer (Floor 3) (Coex Convention Center)

Won Suck Yoon, PhD , Korea University, Seoul, South Korea

Young Yoo, MD, PhD , Allergy Immunology Center, Korea University, Seoul, South Korea

BACKGROUND: MicroRNAs (miRNAs) modulate gene transcription in response to environmental stressors and other stimuli. A role for miRNAs in inflammation and immunity has been demonstrated and further evidence suggests that miRNAs also play a role in atopic dermatitis. In this study, we hypothesized the immune suppression using miR-432 would be induced therapeutic effects on atopic diseases.

METHODS: The Ig-E, Interleukin-4 (IL-4), CCL22 and interferon-g (IFNg) were examined after treatments with miRNAs in murine atopic model. In addition, atopic patient's blood samples were collected and examined for miRNA expression.

RESULTS: miR-432 reduced CCL22 chemokine gene in activated lymphocytes. In mice with a cutaneous disease similar to atopic dermatitis, Interleukin-4 was inhibited and interferon-γ was induced after treatments with miR-432. Furthermore, miR-432 levels were suppressed in the atopic patients. 

CONCLUSIONS: miR-432 suppressed Th1 immune responses and induced therapeutic effects in atopic mouse model.