4055 Mannan-Binding Lectin Serum Levels in Healthy Mongolian Adults

Saturday, 17 October 2015
Hall D1 Foyer (Floor 3) (Coex Convention Center)

Enkhbayar Bazarsad, MD , Physiology and Molecular Biology, Ach Medical University, Ulaanbaatar, Mongolia

Logii Narantsetseg2, Munkhbayarlakh Sonomjamts3


2 Department of Cellular Biology and Biochemistry, School of Pharmacy and Bio-Medicine, Mongolian National University of Medical Sciences, Ulaanbaatar, Mongolia

3 School of Medicine, Mongolian National University of Medical Sciences, Ulaanbaatar, Mongolia



Backround. Mannose-binding lectin (MBL) is a protein, which contains lectin and collagen domains, synthesized in the liver. MBL binds to N acetylglucosamine and mannan structures on the surface of bacteria, fungi, viruses and protozoa, leading to opsonization, phagocytosis and activation of complement system through lectin pathway, independent of an antibody. MBL is a vital protein of innate immune system and has two critical functions: complement activation through the lectin pathway and opsonization. Low level of serum MBL is associated with increased susceptibility to infections and high risk of some allergic and autoimmune diseases.

Purpose. The purpose of our study was to determine the profile of MBL serum level in Mongolian healthy population the first time.

Method. We were collected 112 serum of Mongolian healthy adult blood donors: 58 males and 54 females in 4 different age groups (20-30, 31-40, 41-50 and 51-60). Their mean age was 37.5 years. We were analyzed for MBL level in serum by using double-antibody sandwich ELISA method.

Results. The mean and median serum levels of MBL were 2165.07 ± 711.7 ng/ml and 2172.9 ng/ml.

MBL level in male were 2073.33 ± 672.4 ng/ml, female 2250.63 ± 726.4 ng/ml. No association was observed between sex and MBL concentrations.

2483,44 ± 697.58 ng/ml at 20-30 years of age, 2171,73 ± 743.46 ng/ml at 31-40 years, 1806,66 ± 601.26 ng/ml at 41-50 years and 2144,02 ± 493.4 ng/ml in 51-60 years. There were no significant differences in the mean concentration of MBL among different age groups. 


Conclusions.  MBL serum level of Mongolian healthy population is comparatively higher than some other nations’ population. The MBL values of this study can be used as a normal reference range for future studies in Mongolian population.