4050 Mannan-Binding Lectin Serum Levels in Atopic Mongolian Adults

Saturday, 17 October 2015
Hall D1 Foyer (Floor 3) (Coex Convention Center)

Enkhbayar Bazarsad, MD , Physiology and Molecular Biology, Ach Medical University, Ulaanbaatar, Mongolia

Logii Narantsetseg 2, Munkhbayarlakh Sonomjamts 3


2 Department of Cellular Biology and Biochemistry, School of Pharmacy and Bio-Medicine, Mongolian National University of Medical Sciences, Ulaanbaatar, Mongolia

3 School of Medicine, Mongolian National University of Medical Sciences, Ulaanbaatar, Mongolia



Backround. Mannan-binding lectin (MBL) is a serum protein involved in opsonization and complement activation, which contains lectin and collagen domains, synthesized in the liver. MBL binds to N-acetylglucosamineand mannan structures on thesurface of bacteria, fungi, viruses and protozoa, leading to opsonization, phagocytosis and activation ofcomplement system through lectin pathway, independent of an antibody. Most of the allergic diseases are dominated by the preferential development of specific Th2 type of adaptive immune responses against innocuous antigens in atopic individuals. Low level of serum MBL is associated with increased susceptibility to infectionsand high risk of some allergic and autoimmune diseases. The recently assigned roles of MBL in inflammatory diseases due to increased complement activation have stimulated research into the contribution of MBL and its associated complement activity in asthma and respiratory allergy.

Purpose. Main aim of our study was to determine theprofile of MBL serum level in Mongolian atopic subjects.

Method. Blood samples were collected from Mongolian individuals (n=216) with allergic rhinitis: 86 males and 130 females in 4 different age groups (20-30, 31-40, 41-50 and 51-60). Their mean age was 32.5 years. All subjects had a positive reaction on skin prick tests to one or more inhalant allergens. We were analyzed for MBL level in serum by using double-antibody sandwich ELISA method.

Results.The mean and median serum levels of MBL were 3088.29 ± 671.4 ng/ml and 3147.09 ng/ml.

MBL level in male were 3012.8± 787.8 ng/ml, female 3138.2± 583.1 ng/ml. No association was observed between sex and MBL concentrations in serum.

3192,11 ± 536,64ng/ml at 20-30 years of age, 2994,28 ± 695,41ng/ml at 31-40 years, 3279,24 ±537,36ng/ml at 41-50 years and 2608,08 ± 1008,15ng/ml in 51-60 years. There were no significant differences in the mean concentration of MBL among different age groups. 


Conclusions. MBL serum levelof Mongolian allergic patients is comparatively higher than some other reported study.