2055 Der p 1, Der p 2 and Der p 10 IgE Reactivities in Allergic Rhinitis Patients in Korea

Thursday, 15 October 2015
Hall D1 Foyer (Floor 3) (Coex Convention Center)

Kyu Young Choi, MD , Department of Otorhinolaryngology-Head and Neck Surgery, Hallym University College of Medicine, Seoul, South Korea

Dong-Young Kim, MD, PhD , Seoul National University, Seoul, South Korea

A) Background: To evaluate the IgE reactivity profiles to purified house dust mite (HDM) allergen molecules (i.e. nDer p 1, rDer p 2 and rDer p 10) in Korean allergic rhinitis (AR) patients. Also, symptomatic and serologic changes after sublingual immunotherapy (SLIT) were analyzed according to positive IgE profiles.

B) Methods: Sixty AR patients already diagnosed to have HDM allergy were analyzed for the presence IgE antibodies against nDer p 1, rDer p 2, rDer p 10 and native Dermatophagoides pteronyssinus (Dp). Symptom scores and laboratory tests were followed-up after SLIT.

C) Results: Prevalence rates of IgE for Dp, Der p 1, Der p 2 and Der p 10 were 100%, 98.3%, 93.3% and 8.3%, respectively. After one year of SLIT, symptom scores and laboratory findings improved but did not show significant difference between Der p 10-positive and -negative patients.

D) Conclusions: In Korean AR patients, specific IgE to Der p 1 or Der p 2 presents in most of Dp-allergic patients, while reactivity to Der p 10 is very low. Changes in symptom and serology after SLIT (not containing the allergen Der p 10) did not differ much between Der p 10-positive and -negative patients.