1166 The Sensitization Model and Correlation of Bermuda and Timothy Grass Pollen Allergen in Allergic Patients in Southern China

Wednesday, 14 October 2015
Hall D1 Foyer (Floor 3) (Coex Convention Center)

Wenting Luo, MD , Allergy Department, First Affiliated Hospital of Guangzhou Medical University, Guangzhou Institute of Respiratory Diseases, Guangzhou, China

Baoqing Sun, MD , State Key Laboratory of Respiratory Disease, First Affiliated Hospital Guangzhou Medical University, Guangzhou, China

Background

Using the allergen components detection technology, to study on the sensitization model and correlation of bermuda and timothy grass pollen allergen in respiratory allergic patients in Southern China.

Methods

258 cases of patients with allergic diseases, including 92 asthma patients, 78 allergic rhinitis patients, 88 rhinitis with asthma, 43 children, 215 adults. Serum sIgE of bermuda and timothy were detected by ImmunoCAP100. If the bermuda-sIgE were positive, sIgE of Cyn d 1, Phl p 1, Phl p 4, peanut, Ara h 1, Ara h 8, birch, Bet v 1 and CCD were tested.

Results

1, 22.5%(58/258) patients were sIgE-positive to bermuda, 13.6%(35/258) sIgE-positive to timothy. The positive rate of bermuda and timothy had no significant differences between children and adult, nor between male and female groups(P>0.05).

2, 53.5%(31/58) bermuda sIgE-positive patients were sensitized to Cyn d 1. The concentration of sIgE of bermuda in Cyn d 1 positive patients were significantly higher than Cyn d 1 negative levels(Z=3.103, P=3.103).

3, In the 58 bermuda sIgE-positive patients, 35 patients were timothy sIgE-positive. The concentration of sIgE of bermuda in timothy positive patients were significantly higher than timothy negative(Z=4.735, P=4.735).

4, 100%(35/35) timothy-positive patients were sensitized to Phl p 4 , but only 17.1%(6/35) were positive to Phl p 1.

5, 56.90%(33/58) bermuda-positive patients with were sensitized to peanut. Ara h 1 were positive in 6 patients with peanut-sIgE higher than 17.5kU/L. 3 of them were sensitized to Ara h 8. 32.76%(19/18) were sensitized to birch. 6 cases of birch-positive were sensitized to Bet v 4, which sensitized to Ara h8 simultaneously.

6, 39.66%(23/58) bermuda-positive patients with CCD sensitization, and CCD sIgE levels had good correlation with bermuda, Cyn d 1, peanut, birch, timothy and Phl p 4(P<0.001).

Conclusion

22.5% patients were sIgE-positive to bermuda grass and 13.6% sIgE-positive to timothy grass in Southern China. Bermuda sIgE-positive patients were sensitized to timothy grass, peanuts, CCD and birch and related components in different degree. 53.45% bermuda-positive patients were sensitized to Cyn d 1, and the higher of bermuda sIgE level, the more likely to sensitize to Cyn d 1. 100% timothy-positive patients were sensitized to Phl p 4 , but only 17.1% were sensitized to Phl p 1. 18.18% peanut sensitization patients were sensitized to Ara h 1, 9.09% were reacted to Ara h 8. 31.57% birch-positive patients were sensitized to Bet v 4. CCD had good correlations with grass pollen, peanut and birch allergens, indicated wide cross-reaction between them were caused by carbohydrate cross-react determinants.