Thursday, 15 October 2015
Hall D1 Foyer (Floor 3) (Coex Convention Center)
Dong Won Park, MD
,
Department of Internal Medicine, Hanyang University College of Medicine, Seoul, South Korea
Ji Young Yhi, MD
,
Department of Internal Medicine, Hanyang University College of Medicine, Seoul, South Korea
Ji-Yong Moon, MD
,
Department of Internal Medicine, Hanyang University College of Medicine, Seoul, South Korea
Sang-Heon Kim, MD
,
Department of Internal Medicine, Hanyang University College of Medicine, Seoul, South Korea
Tae Hyung Kim, MD
,
Department of Internal Medicine, Hanyang University College of Medicine, Seoul, South Korea
Jang Won Sohn, MD
,
Department of Internal Medicine, Hanyang University College of Medicine, Seoul, South Korea
Dong Ho Shin, MD
,
Department of Internal Medicine, Hanyang University College of Medicine, Seoul, South Korea
Ho Joo Yoon, MD
,
Department of Internal Medicine, Hanyang University College of Medicine, Seoul, South Korea
Background: Anti-tuberculosis drugs (ATD) are major causes of drug induced liver injury (DILI) around the world. Compared with general population, the patients with connective tissue diseases (CTD) are suspected to be at higher risk of DILI, since they are frequently exposed to various medications including immunosuppressive agents. We aimed to assess the incidence and severity of DILI in CTD patients in comparison with non-CTD patients.
Methods: In this retrospective case control studies, we enrolled the patients with newly diagnosed tuberculosis and treated with the first line ATD for two years in a university hospital. DILI was defined as increase of serum aspartate aminotransferase (AST) and/or alanine aminotransferase (ALT) greater than threefold of the upper limit of normal (ULN).
Results: Of a total of 279 enrolled patients, 40 patients (14.3%) had CTD, such as rheumatoid arthritis (n = 19), systemic lupus erythematosus (n = 10) and ankylosing spondylitis (n = 6). The frequency of DILI caused by ATD in CTD patients was not significantly different from non-CTD patients (7.5% vs. 11.3%, P = 0.346). While severe DILI (AST/ALT > 5 x ULN) was observed more frequently in CTD than controls, there was no statistical significance (7.5% vs. 5.9%, P = 0.451).
Conclusion: The frequency of DILI in patients with CTD was not significantly different from non-CTD patients. These findings suggest that CTD is not a significant risk factor for DILI induced by ATD.
