Methods: We enrolled 390 adult patients with chronic spontaneous urticaria who were followed in the Allergy and Clinical Immunology Clinic in Ajou university hospital from March 2009 to December 2012. The CU-QOL questionnaires, urticaria activity score (UAS), the presence of angioedema, and serum total IgE levels were investigated.
Results: The average CU-QOL scores was 70.6 of 100 points. The CU-QOL scores significantly correlated with the UAS, particularly with our 15-point UAS (UAS15, coefficient -0.532, P <0.01) than the 6-point UAS (-0.502, P<0.01). Total CU-QOL scores significantly decreased in patient with severe CU (UAS15 score≥13) than non-severe CU (52.3 vs 72.1, P <0.001). In cases having angioedema, the urticaria symptom domain scores significantly decreased (37.4 vs 46.9, P = 0.004) than those with urticaria only. Multivariate analysis showed that severe CU, high log[total IgE], and the presence of angioedema were significant predictors of CU-QOL impairment (<85 points).
Conclusions: It is important to consider QOL impairment and severe CU, log[total IgE], and the presence of angioedema are significant CU-QOL predictors in Korean patient with CU.