2144 Dusty Air Pollution Are Associated with an Increase Risk of Allergic Diseases in General Population

Thursday, 15 October 2015
Hall D1 Foyer (Floor 3) (Coex Convention Center)

Mohammadkazem Gheiby, MD , 1. Department of Immunology, Asthma and Allergy, Bushehr, Iran

Shokrollah Farrokhi, MD, PhD , Department of Immunology, Asthma and Allergy, Bushehr University of Medical Sciences, Bushehr, Iran

Background. Concerns have been raised about the adverse impact of dusty air pollution (DAP) in Iran on human health; but there is no study showing the effect of DAP on immune system toward allergic diseases.

Methods. The effects of ambient DAP exposures (based on PM10) on cytokine profiles and lymphocyte immunophenotypes in blood among 148 individuals of general population in hazardous (AQI >300) and good condition weather (AQI <50) was examined. We measured cytokine production (IL-4, IL-10, IL-13, IFN-γ) using ELISA as well as blood samples using a FACSort flow cytometer to determine phenotypes of T-lymphocytes (CD4+ and CD8+), CD19+ B-lymphocytes, CD25+ and CD4+ CD25+ cells.

Results. The mean serum level of IL-4 (33.4 2.9 vs 0.85 0.65 pg/dl) and IL-13 (15.1 4.4 vs 0.12 0.7 pg/dl) in subjects who exposure to ambient DAP were increased significantly than individuals in good condition weather (P= 0.001 for both). In addition, CD19+ B-lymphocytes (12.6 4.9 vs 8.9 3.2%) and CD4+ CD25+ cells (13.6 4.6 vs 7.7 3.8%) counts in peripheral blood were increased parallel with increased DAP exposure levels (P= 0.035 and P= 0.004, respectively).

Conclusions. The study may suggest ambient DAP may affect immune system shifting allergic inflammation in general population.

Key words. Dusty air pollution, immune system, allergic diseases, cytokine, lymphocyte