Methods : One hundred twenty-five AD children were assessed according to the SCORAD index. (mild< 15, moderate 15-40, severe > 40). Serum specific IgE to egg white, cow’s milk, soy bean, wheat, peanut and house dust mite(Df) was measured by ImmunoCAP system or skin prick test. Serum IL-4, IL-10, IL-17, INF-γ were measured by means of flow cytometry(Luminex-200Ⓡ).
Results : Bronchial asthma and allergic rhinitis were combined more frequently in mild atopic dermatitis. However, there were no differences in allergic diseases of family. There was no difference in total IgE among 3 groups. However, serum total eosinophil count was highest in severe atopic dermatitis.(P<0.05) Sensitizatioin rates to egg white, cow’s milk, soy bean, peanut and wheat were increasing significantly according to the SCORAD index.(P<0.05) Sensitization rate to house dust mite was no significant difference according to the SCORAD index.(P=0.55) Although there were no differences in serum IL-4, IL-17 and INF-γ levels among 3 groups, IL-10 was highest in severe atopic dermatitis.(P<0.05)
Conclusions : We suggest that sensitization rates to common food allergens are higher in severe AD and serum IL-10 level is higher in severe AD.