1016 The Role of Vasoactive Intestinal Peptide in the Pathophysiology of Acute Asthma

Wednesday, 14 October 2015
Hall D1 Foyer (Floor 3) (Coex Convention Center)

Olga Semernik, PhD , Rostov State Medical University, ROSTOV-ON-DON, Russia

Background: Previous research has shown neurohumoral factors to play an important role in the pathogenesis of asthma in children. The relationship between plasma levels of norepinephrine, vasoactive intestinal peptide and cortisol and clinical status and pulmonary function in patients with asthma during the period of exacerbation have been investigated.
Method: 30 children (aged 6 to 18 years) with asthma were examined in accordance with the purpose of the study. The control group consisted of 30 healthy volunteers of the appropriate age and gender. We compared clinical severity, spirometry, and neuroendocrine factors at asthmatic patients and healthy volunteers. We used multiple analyses of variance (repeated measures) to interpret the data. In addition, we used the Pearson Product Moment Test to investigate correlations among the different variables.
Results: The levels of vasoactive intestinal peptide, norepinephrine and cortisol were significantly higher in patients with asthma than in healthy volunteers (P < 0.001). It was found the concentration of VIP in serum at patients with asthma during the period of exacerbation to be 110.60 ± 11.89 nmol/l, that was significantly higher than the control group values - 53.26 ± 16.08 nmol / l  (p = 0.016).  In patients with asthma during the period of exacerbation, the level of vasoactive intestinal peptide correlated positively with the clinical severity rating (r = 0.621, P < 0.01) and negatively with FEV1 (r = -0.768, P < 0.001). In patients with mild attack of asthma concentration  VIP in blood was 88.81 ± 31.14 nmol/l, with moderate - 100.27 ± 16.27 nmol/l, severe - 107.34 ± 22.70 nmol/l. In addition, the clinical severity rating showed a negative correlation with FEV1 (r = -0.359, P < 0.01). It can be assumed that the mobilization of the body defense at a child in the acute period of the disease in the form of additional ejection neurotransmitter and it can lead to a more rapid relief of obstruction airway.
Conclusion: It was found the vasoactive intestinal peptide to be the only neuroendocrine factor closely associated with clinical severity and pulmonary function suggesting this factor play an important role in the pathophysiology of acute asthma.