Background. Drug allergy and its negative effects, such as anaphylaxis, constitute an important health problem worldwide.
Objective. To determine the relationship between familial and personal antecedent of allergy, active smoking, and alcohol consumption with drug allergy in pregnant adolescents.
Methods. We conducted research on 785 pregnant adolescents by means of a cross-sectional study. Data collection was performed by using a self-administered questionnaire. We evaluated the difference of drug-allergy risk in 785 pregnant adolescents through familial and personal antecedent of allergy, active smoking, and alcohol consumption, calculating Odds ratios (OR) and 95% Confidence intervals (95% CI) by both uni- and multivariate regression analyses.
Results. Prevalence of drug allergy was 9.2% and of familial and personal antecedent of allergy, 8.7 and 21.0%, respectively. Percentage of active smoking was 17.6% and of alcohol consumption, 38.1%. Results of multivariate logistic regression analysis show that the familial history of atopic (Adjusted OR = 3.51; 95% CI = 1.85‒6.29; p = 0.000), personal antecedent of allergy (Adjusted OR = 4.11; 95% CI = 2.48‒6.81; p = 0.000), active smoking (Adjusted OR = 1.92; 95% CI = 1.10‒3.35; p = 0.021), and alcohol consumption (Adjusted OR = 2.44; 95% CI = 1.48-4.06; p = 0.000), are significantly associated with drug allergy.
Conclusion. Familial and personal antecedent of allergy, active smoking, and alcohol consumption appear to be important factors for development of drug allergy in pregnant adolescents aged 13-19 years.