3040 Time Trends in the Epidemiology of Recurrent Wheezing in Infants from South America

Friday, 16 October 2015
Hall D1 Foyer (Floor 3) (Coex Convention Center)

Herberto Jose Chong Neto, MD, PhD , Pediatrics, Professor of Pediatrics, Federal University of Parana, Curitiba, Brazil

Gustavo Falbo Wandalsen, MD, PhD , Federal University of Sao Paulo, Sao Paulo, Brazil

Ana Caroline Dela Bianca, PHD , Universidade Faderal De Pernambuco, Recife, Brazil

Carolina Aranda, M.S.c. , Federal University of Sao Paulo, WAO Junior Member, São Paulo, Brazil

Nelson Rosario Filho, MD PhD , Pediatrics, University of Parana, Curitiba, Brazil

Dirceu Sole, MD, PhD , Sao Paulo Federal University, Brazilian Society, Sao Paulo, Brazil

Javier Mallol, MD , Department of Pediatric and Respiratory Medicine, University of Santiago De Chile (USACH), Santiago, Chile

Luis Garcia-Marcos, MD, PhD , Pediatric Respiratory and Allergy Units, Arrixaca University Children's Hospital. University of Murcia, Murcia, Spain

Background: The changes over time in the prevalence and severity of recurrent wheezing (≥3

wheezing episodes) in infants, are virtually unknown. To determine the trend of RW prevalence and

severity of RW in infants during the first year of life between two surveys separated by seven years.

Method: This is a part of International Study of Wheezing in Infants (EISL), a population-based

study, in infants aged 12-15 months, compares data from two surveys (S1 and S2) performed using

the same methodology, in three large cities that participated in both surveys: Curitiba and São Paulo

(Brazil) and Santiago (Chile).

Results: The average prevalence of wheezing once or more during the first year of life decreased

from 52.9% (95%CI 51.8-54) in S1 to 46.9% (95%CI 45.2-48.07) in S2, p = 0.0001. There was a

significant decrease in the mean prevalence of RW between S1 (23.3%, 95%CI 22.3-24.3) and S2

(20.4%, 95%CI 19.0-21.8), p=0.004. In infants with RW the mean prevalence of severity markers

between S1 and S2 remained high (severe episode: 56.9% to 54.2%, p = 0.32); ED visits (68.1% to

70.9 %, p = 0.21), with a significant increase in admissions for wheezing (21.1% to 26.7%, p =


Conclusion: the prevalence of RW and severity markers during the first year of life remained high

between both surveys. The infants who suffer from RW have markedly high prevalence of severity

markers as visits to ED and admissions for wheezing, indicating that an important group of these

infants has a troublesome progression that certainly affect quality of life and put infants at risk of

more severe complications.