Objective: To assess the roles of ADAM 10 and ADAM 17 in allergic rhinitis by assaying for expression of these materials.
Methods: The expression of ADAM 10 and 17 was investigated in the allergic nasal mucosa compared with non-allergic nasal mucosa. Tissue samples were analyzed by real time polymerase chain reaction (PCR) and Western blotting.
Results: The ADAM17 mRNA and protein levels were significantly lower in allergic nasal mucosa than in the non-allergic nasal mucosa (P < 0.05). The ADAM10 mRNA did not differ significantly between allergic nasal mucosa and non-allergic nasal mucosa. ADAM10 protein levels were significantly higher in the non-allergic nasal mucosa than in the allergic nasal mucosa (P < 0.05).