Saturday, 17 October 2015
Hall D1 Foyer (Floor 3) (Coex Convention Center)
Anaphylaxis induced by ofloxacin has been rarely reported, and its pathogenetic mechanism has not yet been fully understood. This is a report of non-IgE mediated ofloxacin-induced anaphylaxis in a 20-year-old female patient who suffered from allergic rhinitis and had a previous history of acute urticaria induced by nonsteroidal anti-inflammatory drugs. She developed generalized urticaria and anaphylaxis following oral ingestion of ofloxacin. When we measured specific serum antibodies to ofloxacin-human serum albumin (HSA) conjugate using ELISA, a high level of specific serum IgG4 was detected, but serum specific IgE was not detectable. Moreover, a basophil activation test showed a significant up-regulation of CD203c with addition of ofloxacin and anti-IgG4 antibody in the patient with no significant changes in 3 non atopic healthy controls. These findings suggest that ofloxacin can induce anaphylaxis via pathogenetic mechanisms involving non IgE-mediated, but specific IgG4-mediated responses.