House-dust mites (HDMs) are important sources of indoor allergens. Our aim was to define the sensitization rate of specific immunoglobulin E (IgE) in Der p and its components and investigate their clinical features in children with allergic disease.
We performed a prospective evaluation of 80 HDM sensitized patients with histories of allergic rhinitis (AR), atopic dermatitis (AD), asthma and urticaria (UC). The patients underwent an allergen identification test using ImmunoCAP for total IgE, Der p, Der f, Der p 1, Der p 2, and Der p 10.
Seventy-nine patients had detectable serum levels of Der p specific IgE, and 80, 66, 63, and 7 patients were sensitized to Der f, Der p 1, Der p 2, and Der p 10, respectively. The level of Der p 1-specific IgE was significantly lower in the UC group than in the AD and AR groups. Total IgE level was significantly higher in the Der p 10-sensitized group. Der p 10 serum IgE level was highly correlated with crab and shrimp specific IgE. A significant positive correlation was observed between total IgE and specific IgE to Der p and its components and Der f.
Sensitization to HDM and its components in our study is similar to that reported in previous studies from temperate climate. There was a significant difference in Der p 1 in patients with UC, AD and AR.