Aim: investigate dynamics of immunological biomarkers in children with food allergy wich used goat milk formula supplementation.
Materials and methods: We examined 66 infants with food allergy aged from 1 to 12 months, who were on the artificial feeding using goat milk formula. The dynamics of immunoregulatory substances IL-2,-4,-5,-10,-13, TGF-β1 and allergen-specific IgE and IgG antibodies to cow milk protein, α-lactalbumin, β-lactglobulin, casein, soy and goat milk were measured by immunoenzime method. Observation duration was 28-30 days.
Results: Dynamics of immunological biomarkers characterized decreased levels of allergen-specific IgG antibodies to the cow milk protein and its fractions, reduced levels of allergen-specific IgE antibodies to the cow milk protein and α-lactalbumin, and reduction of IL-4, -5, levels. These changes were correlated with clinical food allergy symptoms reduction.
Concluson: assessment of of allergen-specific IgG antibodies to the cow milk protein and its fractions, allergen-specific IgE antibodies to the cow milk protein and α-lactalbumin, IL-4 and IL-5 can be used for immunology evaluation of the effectiveness goat milk formula supplementation.