12-3SY Clinical Phenotypes and Molecular Mechanisms of Severe Asthma

Friday, 16 October 2015: 11:45 - 12:05
Grand Ballroom 104 (Coex Convention Center)

Koichiro Asano, MD , Division of Pulmonary Medicine, Department of Medicine, Tokai University School of Medicine, Kanagawa, Japan

Learning Objectives:
Due to the heterogeneity of severe asthma, there is no “standard” treatment and individualized treatment is mandatory. Unsupervised cluster analysis has identified several clinical phenotypes such as early-onset allergic asthma, later-onset obese asthma, later-onset eosinophilic asthma, etc. Furthermore, molecular phenotyping, based on the gene expression profiles in the airways or blood cells, has identified Th2-high/low phenotypes with different levels of serum periostin. In the present symposium, I will first discuss the similarities and differences between “periostin-high” and “eosinophilic” phenotypes of severe asthma. Secondly, I will present a possible mechanism of corticosteroid-insensitivity in “innate-type allergy” induced by group 2 innate lymphoid cells (ILC2s).