Wednesday, 7 December 2011: 12:45 - 13:00
Gran Cancún 2 (Cancún Center)
Giovanni Melioli, MD
,
Laborario Centrale di Analisi, Istituto Giannina Gaslini, Genoa, Italy
Laura Marcomini, BS
,
Laborario Centrale di Analisi, Istituto Giannina Gaslini, Genoa, Italy
Alessia Agazzi, BS
,
Laborario Centrale di Analisi, Istituto Giannina Gaslini, Genoa, Italy
Gyada Bazurro, BS
,
Laborario Centrale di Analisi, Istituto Giannina Gaslini, Genoa, Italy
Lucilla Rossi
,
Laborario Centrale di Analisi, Istituto Giannina Gaslini, Genoa, Italy
Mariangela Tosca, MD
,
UO Pediatria ad indirizzo penumologico ed allergologico, Istituto Giannina Gaslini, Genoa, Italy
Paola Minale
,
Allergologia, AOU San Martino, Genoa, Italy
Renato Rossi
,
Rete di Allergologia Regione Piemonte, Azienda Sanitaria Cuneo 1, Cuneo, Italy
Giovanni Passalacqua, MD
,
Allergy & Respiratory Diseases, Universita Degli Studi Di Genova, Genoa, Italy
Giorgio Walter Canonica, PhD
,
Allergy & Respiratory Diseases, Universita Degli Studi Di Genova, Genova, Italy
Background: The allergic march is well know at the level of pattern of sensitisation, but there is no information of its evolution in term of sensitzation to single allergenic molecules. We investigated the evolution of the IgE repertoire by means of a microarray allergen assay.
Methods: Serum samples from allergic patients of a wide age range were analyzed by a micorarray chip, which allows to identify in a single assay the presence of specific IgE towards 103 allergenic molecules. Total IgE were also evaluated as an internal control. Patients were stratified in 6 groups according to their age (0-2; 3-5; 6-9; 10-13; 14-17 and >17 years).
Results: Samples from 609 patients were analysed. The behaviour of total IgE according to age strictly paralleled that of the sum of specific IgE. Food-related components were the more frequently recognized in the first ages, whereas specific IgE to plant allergens appeared later. Nonetheless, mite-specific IgE were the most represented in all age classes. Specific IgE against cross-reacting allergens were virtually absent in the first years and tended to appear after the age of 6.
Conclusions: The molecular pattern of allergen recognition according to age, well reflects the clinical characteristics of the allergic march.
