Triptorelin is a drug that is frequently used in pediatrics to treat precocious puberty -an often condition in childhood endocrinology services. Despite its widespread use, there are not much research on hypersensitivity reactions to this drug. We found three patients that have suffered allergic reaction during the treatment with Triptorelin
Methods:
We treat three eight years old girls -diagnosed with precocious puberty- that have suffered allergic reaction during the treatment with Triptorelin.
Patient 1: An hour after the first dose the patient broke out in a rash over her face, trunk and upper limbs, she also showed general paleness, conjunctival erythema, arthralgia and joint swelling in both knees with functional impotence of the lower limbs.
Patient 2: Five minutes after the second dose the patient showed anaphylactic reaction.
Patient 3: Two hours after the second dose the patient showed generalized urticaria and tachycardia
Results:
Once overcome those events. We started to provoke the reaction by doing the progressive-controlled triptorelin test. Finally we could confirm the hypersensitivity reaction to this drug
Conclusions:
The triptorelin is a drug that may cause hypersensitivity reaction. So, after the first application, we recommend to monitor the patient and also plan some actions to avoid a possible anaphylactic shock event