Rocío Meza-Velazquez, MD
,
Investigacion, Universidad Juarez del Estado de Durango, Gomez Palacio, Dgo, Mexico
Raquel Concepción Goytia Acevedo, PhD
,
Investigation Department, Universidad Juárez Del Estado De Durango, Gómez Palacio, Durango, Mexico
Guadalupe García-Arenas, PhD
,
Investigacion, Universidad Juarez del Estado de Durango, Gómez Palacio, Dgo., Mexico
Emma S. Calderon Aranda, PhD
,
Toxicologia, CINVESTAV-Mexico, D.F., Mexico
Manuel Rosales Gonzalez, PhD
,
Investigación, Universidad Juárez del Estado de Durango, Gómez Palacio, Dgo., Mexico
Marisela Rubio-Andrade, MD
,
Investigación, Universidad Juárez del Estado de Durango, Gómez Palacio, Dgo., Mexico
Aurora Maravilla-Domínguez, MD
,
Investigación, Universidad Juárez del Estado de Durango, Gómez Palacio, Dgo., Mexico
Mariano Enrique Cebrian, PhD
,
Toxicologia, Centro de Investigación y de Estudios Avanzados del IPN, DF, Mexico
Jorge Luis Rosado, PhD
,
Facultad de Ciencias Naturales, Universidad Autónoma de Querétaro, Queretaro, Mexico
Rebeca Stoltzfus, PhD
,
Division of Nutritional Sciences, Cornell University, Ithaca, NY
Gonzalo Gerardo García Vargas, PhD
,
Investigación, Universidad Juárez del Estado de Durango, Gómez Palacio, Mexico
Background: There are precedents that suggest gender differences in the relationship of lead in blood with serum total IgE. The aim of this study was to evaluate in a population of teenagers attending nine schools in Torreon, Coahuila, the relationship of lead in blood with total IgE and their dependence on gender.
Methods: We included 230 teenagers (105 females, 125 males) between 11 and 14 years of age, from a cohort of children evaluated for its history of lead exposure since 2000. Clinical diagnosis was performed to detect allergies; skin tests were applied for 47 common allergens in the region. IgE levels were quantified in serum by chemiluminescence and the blood lead levels by spectrophotometry AAS.
Results: The average blood lead levels in allergic group were of 4.86 ± 2.9μg/dL and in the non-allergic group 5.1 ± 2.7 µg/dL. There were not gender differences between allergic group vs. non allergic group, however, among the types of allergic diseases, a higher percentage of males had rhinitis, conjunctivitis and asthma, compared with the females. The blood lead level in males was significantly higher (5.61 ± 3.3 mg / dL) compared with females (4.22 ± 2.1 mg / dL) and the regression analysis between blood lead levels with total IgE was significant in males and not in females.
Conclusions: Gender differences observed appear to be explained by blood lead levels, however, we should consider the contribution of other variables in the model.
