4029 The Examination of the Association Between the Chronic Rhinosinusitis and the Inflammation of the Lower Respiratory Airway by Using the Exhaled Nitric Oxide(NO) and the Respiratory Function Test

Wednesday, 7 December 2011
Poster Hall (Cancún Center)

Hiroyoshi Yoshinami, MD, PhD , Otorhhinolaryngology, Saitama Medical University, Saitama, Japan

Masanobu Shinogami, MD, PhD , Otolaryngology, Tokyo Metropolitan Police Hospital, Tokyo, Japan

Ryoji Kagoya, MD , Otolaryngology, Tokyo Metropolitan Police Hospital, Tokyo, Japan

Masato Nakashima, MD, , Otorhinolaryngology, Saitama Medical University, Saitama, Japan

Isao Wada, MD, PhD , Otorhinolaryngology, Saitama Medical University, Saitama, Japan

Tutumiuchi Katuhiro, MD, , Otorhinolaryngology, Saitama Medical University, Saitama, Japan

Tetsuo Ikezono, MD, PhD, Prof , Otorhinolaryngology, Saitama Medical University, Saitama, Japan

Yasuhiro Kase, MD, PhD, Prof , Otorhinolaryngology, Saitama Medical University, Saitama, Japan

Makoto Nagata, MD, PhD, Prof , Allergy Center , Department of Respiratory Medicine, Saitama Medical University, Moroyama-Machi, Japan

Background:  It is said that the chronic rhinosinusitis influences the lower respiratory airway and there is a report that

 a tendency to increase the eosinophilic rhinosinusitis later, but they are still unknown.

Methods:   We divided the chronic  rhinosinusitis  patients with the adaptation of the operation into four groups and

exaed whether there was a difference in the respiratory function, exhaled NO, and the number of the blood

eosinophil.

Object :   29  patients with chronic rhinosinusitis, who planned the endonasal sinus surgery.

Results:  Comparing these four groups,  it was the worst on the respiratory function (one second rate) in  the 

group  with nasal polyps and without nasal allergy. It was recognized the connection between the respiratory function

and  the presence of the nasal polyps. It was possible that the exhaled NO became the index to the lower airway

inflammation.

Conclusions: We classified the chronic rhinosinusitis and evaluated the lower airway function. It helps the  

pathologic understanding of the chronic rhinosinusitis. And it leads to understand of the influence on the lower airway

inflammation.