Identify the frequency of bronchial hyperresponsiveness in the obese and morbid obese adolescent. Compare the results of the direct challenge with gender and BMI.
Methods:
We analized 215 bronchoprovocation challenge of adolescents from 10 to 18 years old in the 2006-2010 period. We classified them in 3 groups: eutrophic (BMI <p85), obese (BMI p90-99) and morbid obeses (BMI >p99) without smoking contact of pulmonar disease. A basal spirometry was performed according to the ATS guidelines. If the FEV1 was above 80% for age and gender we performed the methacholine challenge. We use the dosimeter method with the following methacholine dilutions: 0.0625mg, 0.25mg, 1mg, 4mg and 16mg. When a provocation concentration caused a 20% FEV1 reduced was considered a positive challenge for bronchial hyperresponsiveness (BHR).
Results:
Of the 215 adolescents in this study: 40 were eutrophic, 116 obese and 59 morbid obese. The methacholine challenge were positive in 12% of eutrophic, 22% of morbid obese and 25% of obese. But there were not a statistically significant difference. Gender were not associated as a risk factor for bronchial hyperresponsiveness. The positive bronchoprovation challege in women was observed in 27.6% of morbid obese, 23.7% of obese and 5% of eutrophic; in men 26.3% of obese, 20% of eutrophic and 16.7% of morbid obese. There were not a stadistically significant difference.
Conclusions:
It is necessary a larger number of patients to concluded that BMI and gender are not associated with increased bronchial hyperresponsivess.