Capsaicin Cough Challenge Testing 

Choon – Sik, Park, M.D., Ph.D.

Genome Research Center for Allergy and Respiratory Diseases,

Division of Allergy and Respiratory Medicine, Soonchunhyang University, Bucheon Hospital.

Aspirin provocation tests for aspirin exacerbated respiratory diseases.

Aspirin-Exacerbated Respiratory Diseases (AERD) refers to the development of bronchoconstriction, and nasal manifestations in asthmatic individuals following the ingestion of aspirin or other nonsteroidal anti-inflammatory drugs. AERD remains widely underdiagnosed in the asthmatic population due to insufficient awareness of the relation of ASA ingestion and asthma exacerbation. Thus, the identification of aspirin hypersensitivity, especially hidden cases from the patients, is essential to avoid the serious complication from them. Diagnosis can be established with certainty only by provocation tests using increasing doses of ASA. There are commonly used 4 types of provocation tests, depending on the route of ASA administration: oral, bronchial (inhaled), intravenous and nasal. In this lecture, indications, contraindications for the tests, the rules of drug withdrawal are reviewed. Protocols of oral, bronchial and nasal aspirin provocation tests are presented with introduction of advantage and disadvantages of each test.