Learning Objectives:
Given the clinical heterogeneity of patients presenting with systemic (and frequently recurrent) MC activation-related symptoms, their recognition and appropriate classification remain a challenge for physicians in daily clinical practice.

The learning objectives are:  

1) To provide diagnostic tools for pathological conditions characterized by systemic and severe mast cell-mediator related symptoms in clinical practice.

2) To define markers for predicting mast cell clonality and, thus, to select patients candidates for a bone marrow study in order to rule out a systemic mastocytosis or a clonal mast cell activation syndrome.

3) To define the relationship between clonal mast cel disorders and anaphylactic risk