1963 Asthma and atopy in children 7 to 9 years after viral respiratory infections

Monday, 6 December 2010
Background. Respiratory syncytial virus infections (RSV) in young children have been associated with developing asthma later on. Previousreports have shown that atopy is common in children with a history of lower respiratory tract  infections with RSV. The aim of this study is to determine asthma and atopy in children 7 to 9 years after viral respiratory infections.

Materials and Methods. This study is a  part of a nested case control study entitled "RSV and recurrent wheezing in Indonesia: 7 - 9 years follow up studywith lung function studies". Pulmonary function tests (PFTs) were obtained, and skin prick test (SPT) were performed using 12 allergens.

Results. A total 218 children, with the mean age 10.4 ± 1.05 years, consisted of 50.9% boys, were enrolled in the study. Fifty two (23.(%) children with history of viral respiratory infections, 46% boys, with mean age 10.5 ± 1.05 years. The SPT were positive in 174 (79.85%) children. Fifteen children have FEV1/FVC ratio ≤ 80%, 4 (26.7%) with history of viral respiratory infections. Further analysis of 52 children showed 65.4% the SPT were positive, 25% negative, and 9.6% showed severe dermatographisms. The most common allergens were blomia tropicalis (50%), dermatophagoides farinae (44.2%), and dermatophagoides pteronyssinus (42.3%). History of atopy in these children showed: urticaria (30.8%), rhinitis (21%), asthma (13.5%), food allergy (9.6%), and eczema (1.9%). The history of atopy in the families were asthma (36.5%), urticaria (32.7%), food allergy (25%), rhinitis (13.5%) and eczema (3.9%).

Conclusion. The rate of asthma is low, however, the presentage of atopy were high. The most common allergens were B. tropicalis, D. farinae, and D. pteronyssinus.