METHODS: Ninety-six children aged 3 to 17 years old were recruited, including 80 with perennial AR and 16 with non-AR as controls. Medical history was taken and physical examination, serum specific IgE, total IgE, peripheral blood eosinophil count, nasal smear were conducted. The nasal symptom score was calculated for each patient from a questionnaire and correlated with laboratory data. Bivariate correlation analysis and multiple linear regression analysis were done to compare the correlation among clinical markers and symptom score.
RESULTS: Levels of all allergic markers in children with AR were significantly different from those in non-allergic children. All of the markers were related to the severity of AR in Pearson correlation analysis. On logistic regression analysis, only serum allergen-specific IgE were independent predictors.
CONCLUSION: These results suggest that serum allergen-specific IgE is correlated with the severity of perennial AR in children.