1701 Combination of a nasal antihistamine olopatadine and a nasal corticosteroid, mometasone for the treatment of seasonal allergic rhinitis patients not currently controlled on monotherapy intranasal antihistamine or intranasal corticosteroid

Wednesday, 8 December 2010
For Seasonal Allergic Rhinitis (SAR) patients that remain symptomatic on an intranasal antihistamine, Olopatadine or intranasal corticosteroid, Mometasone furoate, the combination of intranasal antihistamine, Olopatadine with an intranasal cortiscosteroid Mometasone may provide additional efficacy in sub-optimally controlled Seasonal Allergic Rhinitis Patients.

In this open labeled 8-week trial 40 patients with symptomatic SAR currently using Olopatadine 1330 mgc/nostril BID or Mometasone furoate, 100 mcg/nostril QD were randomized to receive the combination Olopatadine 1330 mcg/nostril BID + Mometasone, 100 mcg/nostril QD. The end points of the trial include: rhinomanometry, nasal symptom score (composite score of nasal congestion, rhinorrhea, sneezing post nasal drip and itching) and flexible rhinopharyngolaryngoscopy examination.

Mean efficacy measurements at the end of the 8-week trial revealed significant improvements in all parameters examined in the combination treatment group as compared to baseline measurements.

In conclusion, the combination nasal Olopatadine plus nasal Mometasone is more effective than monothereapy nasal Olopatadine or nasal Mometasone. It appears that in the combination treatment Olopatadine and Mometasone, the primary end points (rhinomanometry and symptom scores) are significantly improved.