14 months old girl, known with severe atopic dermatitis, debuted at first days of life, had relapsed several staphylococci cutaneous infections, vasculitis like syndrome without positive verification of PCR/Antibody of Herpes family virus and was many times in treatment with per os and i.v. antibiotics. In the first 9 months of age exclusive breastfeedings, but due to event stimulation after mothers diet, stopped. Started with diet restriction, only specific milk formula Neocat, PUFAs , calcitriol and probiotics(LGG). Results: 1) before immunomodulatory therapy, only with skin care and topical CS, intermittent topical calcineurin inhibitors and pruritis control: very high IgE over 5000, over 100 for cows milk, eggs and cross reaction almost of all, one that was normal was fish and shrimps IgE, high Eo counts, 1.68, thrombocytosis and Neu-peni. Calcitrol 204, normal levels of immunoglobulin’s, C1q concentration 77%, slightly below ref. intervals, reduced activity of complement via the MBL pathway and decreased concentration of B cells. 2) After: normalization of Le and Tr counts, especially nice response in Eo are decreasing to 0.53, reduction in IgE level to 2500.EDTA blood for T, B and NK cell: normal proportions and concentrations of T and B / NK lymphocytes, nice response of virgin Tcell, normal exposure of adhesions molecules, normal T cell proliferation by polyclonal stimulation, normal value of somatic mutation. There are no signs of maternal engraftment on the CD4/CD8 separated cells. There is not sign of STAT3 deficiency. Clinical benefit, much better without signs of acute infections and severe itching, almost normal skin without lesions, normal growth.