1684 Study of IL-8 indices in elderly people with femoral neck fractures

Tuesday, 7 December 2010
This study the dynamics of IL-8 rate in patients with osteoporotic femoral neck fractures (a group of patients with subcapital and pertrochanteric fractures).

The level of IL-8 has been studied in 112 patients with osteoporotic fractures of proximal one-third of femoral neck. In the group with subcapital fractures we have revealed a high concentration of IL- 8, which exceeded the controlling group indices by 1.2 times. IL-8 indices in the group of patients with pertrochanteric fractures have not reached statistically significant distinctions.

During the first 24 post-operation hours we have observed in the group of patients with subcapital fractures a growth of IL- 8 rate by 1,2 times (p > 0,05) in comparison with that before the operation. No significant difference with its content was revealed in patients with pertrochateric fractures as compared with the controlling group.

By the 14th day there was registered a tendency to the further growth of IL–8 indices up to 4,2 pg / ml, which was by 1,8 times higher than the level before the operation (p > 0,05). On the contrary, there was an IL-8 decline to the lower level registered in the group with pertrochanteric fractures as compared to the controlling group indices (1,7 pg / ml).   

According to our research, patients with subcapital fractures of the neck of the femur proved to be the most vulnerable elderly patients. We have also registered the highest percentage of post-operation complications and a more lingering rehabilitation period in this group of patients. It should be noted that women showed higher IL-8 indices (2,15 pg/ml), which were by 1,1 times higher than those of the controlling group.

 It has been determined that during the first post-operation day the IL-8 level exceeded the indices of the controlling group by 1,6 times and on the 14-th day  the elevation was by 2,2 times higher, which amounted 2,93pg/ml and 4,2pg/ml accordingly. The fact in question may serve as a diagnostic criterion for the development, diagnosing and treatment of osteoporotic fractures in older and senile patients.