Comparison Between House Dust Mite and Aspergillosis Sensitization in Patients with High Level of Tige

Background：Among the patients with serum total immunoglobulin E (TIgE) higher than 1000ku/L, who suffered from respiratory diseases, we could found the majority of them were sensitized to house dust mite (HDM) and Aspergillosis. We aimed to find out if there any correlation with TIgE among serum specific immunoglobulin- -E (sIgE) against house dust mite along with Aspergillosis in the patients.

Methods:   64 subjects with high level of TIgE were tested for serum sIgE-derp1 and sIgE-Af by using ImmunoCAP 100.

Result：    68.8% (44/64) patients were sensitive to HDM while 40.6% (29/64) were sensitive to aspergillosis. What’s more, 37.5% (24/64) patients could be detected sIgE (derp1,Af) while 15/64(23.4%) patients were found sIgE(derp1,Af)-free. 20/64 (31.3%) patients were merely sensitive to HDM while 5/64 (7.8%) were sensitive to Aspergillosis. Among the patients with TIgE higher than 1000ku/L, those patients sensitive to HDM was significantly more than those sensitive to Aspergillosis (ka=9.00,t= P<0.01). sIgE-Af (r=0.410) was correlated more with TIgE than sIgE-derp1 (r=0.228) was (P<0.05).

Conclusion：Most of the patients with high level of TIgE, complicated with respiratory diseases, were more likely sensitive to HDM rather than Aspergillosis. Compared to sIgE against HDM, sIgE-Af contributed more to the level of TIgE. The detection of sIgE against HDM and Aspergillosis was important for the patients complicated with respiratory and high level of TIgE.